Modelando el transporte de iones de potasio a través de un canal iónico de una membrana celular

Abstract

Conduction models of ion through voltage-gated ion channels, at symmetrical concentration in cellular membrane, have been developed. These channels are highly selective to K or Na ions due to a potential difference. First, it is considered the theory of metallic conduction, where, it is assumed a random distribution of obstacles, which oppose to free motion of ions inside the channel. This spacing distribution among obstacles turned out to be very narrow and its mean value is very small, that implies an almost continuous collision of ion with the channel obstacles. In addition, a model based on the crystal periodic structure is proposed. These models would describe the experimental values of conduction, but the parameters associated to each model would take values that are not easy to verify experimentally, and they are related to the channel structure.